Cytokines and cellular interactions in inflammatory synovitis

I-5: Molcular and Cellular Interactions in UterineReceptivity for Implantation

Background: Though plausible candidate adhesion systems have been identified, current knowledge of embryo-maternal attachment in human is limited by the inability to conduct well-controlled functional investigations. We have sought a viable medium-throughput model for the identification and functional assessment of molecular markers in the initial epithelial phases of implantation. An ideal mod...

Inflammatory Cytokines and type 2 diabetes

Inflammatory cytokines increase in patients with type 2 diabetes (T2D) and metabolic syndrome. This review focuses on inflammatory cytokines such as C-reactive protein (CRP), tumor necrosis factor (TNF-α), and adiponectin, a cytokine produced by adipose tissue and associated with insulin sensitivity. Despite the major role of cytokines in the development of T2D, in the case of adiponectin still...

Hypoxia and inflammatory synovitis: observations and speculation.

In recent years considerable research interest has been directed at studying the biological consequences of tissue hypoxia. As this work progresses it becomes increasingly apparent that tissue hypoxia has complex biological consequences. Much is now known about the natural defences of the body to hypoxia, including heat shock protein synthesis and angiogenesis. These systems are normally under ...

Unbalanced Pro-Inflammatory and Anti-Inflammatory Cytokines Ratio and Endometriosis: A Contributive Pathogenic Role?

Pro-inflammatory cytokines affect pancreatic carcinoma cell. Endothelial cell interactions.

OBJECTIVES The potential role of surgery-induced pro-inflammatory cytokines on the development of tumor recurrence in pancreatic cancer was investigated. MAIN OUTCOME MEASURES The adhesion of 3 human pancreatic carcinoma cell lines, PanC1, MiaPaCa and BxPC3 to monolayers of microvascular endothelial cells after pre-incubation with 0.1 or 10 ng/mL IL-1beta, TNF-alpha or IL-6 was assessed in a ...